August Ayurveda August Ayurveda August Ayurveda

Affluence of mind is true cause of obesity.


          Saturday, June 23, 2018


Our Consultants
Panchakarma Programs
Promotional Support
Document Service
Get Connected
Procure Herbs
Buy Herb Portraits
Order Books
Ayurveda Films
Question and Comments
FREE Online Consultation
Payment Options

Curcumin prevents methylglyoxal-induced oxidative stress

Methylglyoxal (MG) is a reactive dicarbonyl compound endogenously produced mainly from glycolytic intermediates. Elevated MG levels in diabetes patients are believed to contribute to diabetic complications. MG is cytotoxic through induction of apoptosis. Curcumin, the yellow pigment of Curcuma longa, is known to have antioxidant and anti-inflammatory properties. In the present study, we examined the effect of curcumin on apoptotic biochemical events caused by incubation of ESC-B5 cells with MG.

Curcumin inhibited the MG-induced DNA fragmentation, caspase-3 activation, cleavage of PARP, mitochondrial cytochrome c release, and JNK activation. Importantly, curcumin also inhibited the MG-stimulated increase of reactive oxygen species (ROS) in these cells. In addition, we demonstrated that curcumin prevented the MG-induced apoptosis of mouse blastocysts isolated from pregnant mice. Moreover, curcumin significantly reduced the MG-mediated impairment of blastocyst development from mouse morulas.

The results support the hypothesis that curcumin inhibits MG-induced apoptosis in mouse ESC-B5 cells and blastocysts by blocking ROS formation and subsequent apoptotic biochemical events.


<body> <a href="">a</a> </body>

Wellness and Wisdom

Homing on the Remedies

Wellness and Wisdom with Sanjay Parva

Lets talk ayurveda

Stress Management
through Ayurveda

6 Tastes and Healing


Disease management

3 Stages of Awakening

Blue Morphos Butterflies
in the Colombian Jungle:
Success Story with CAM


Weekly business article

8 Countries to Participate
in 'Raj Ayu Con 2013'

Quest for New Treatments
Drives German Doctor
to Ayurveda


The world of ayurveda:

the world of ayurveda
the origin of ayurveda
The ayurvedic concept of life

Contact Us | Disclaimer | Privacy Policy       

Copyright (C) 2013 August Ayurveda Pvt. Ltd.
All rights reserved